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C3-beta-c

abbr. C3bc. This factor is a C-terminal fragment of the beta-chain of rat complement factor C3 and has been isolated from the exudate of the chronic phase of rat carrageenin induced inflammation (Nakagawa and Komorita 1993).

C3-beta-c induces chemotaxis of neutrophils in vivo after injection into the preformed air-pouch on the back of rats. C3-beta-c transiently increases the intracellular free calcium ion concentration of neutrophils and enhances their adhesion to fibrinogen in vitro. At low concentrations (10**-10 to 10**-11 M) the factor stimulates rat macrophages to produce CINC-2-alpha ... ... ... ... ... Subscribe to continue reading! ... ...

 

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