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Brorin-like

[Brain-specific chordin-like protein-like] The approved gene symbol is VWC2L [von Willebrand factor C domain-containing protein 2-like]. This secreted protein of 222 amino acids has been identified by Miwa et al (2009). The protein is similar to Brorin, a secreted BMP antagonist. Recombinant Brorin-like protein weakly inhibits the activity of bone morphogenetic proteins in mouse pre-osteoblastic cells and promotes neurogenesis in mouse neural precursor cells. Brorin-like is expressed predominantly in the adult brain and embryonic neural tissues. The inhibition of Brorin-like functions in zebrafish impairs neural development.

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