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Brain Lymphatic Endothelial Cells

abbr. BLECs. This cell type was described originally as a non-lumenized endocytic cell type of lymphatic developmental origin and molecular expression that resides in the zebrafish meninges (Bower et al, 2017; Van Lessen et al, 2017; Venero Galanternik et al, 2017). It is found also in the brains of mice, and morphologically similar cells co-expressing the same markers are found also in human post-mortem leptomeninges (Shibata-Germanos et al, 2020). The cells reside in close proximity to blood vessels expressing TIE-2, do not associate with vessels that have penetrated into the brain, and are characterised by the expression of VEGFR3. They express the lymphatic markers MRC1 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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