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BP16 peptide

This peptide, KKLFKKILKKL, has been identified as a non-toxic cell-penetrating peptide from a set of antimicrobial peptides selected from a library of cecropin / melittin hybrids (Soler et al, 2014).

BP16 peptide is internalized by cells, including breast cancer cells and pancreas adenocarcinoma cells, mainly through a clathrin dependent endocytic mechanism and localizes in late endosomes. Coupling of BP16 to the anticancer drug chlorambucil, shows that BP16 peptide can be used as a drug delivery vector and improves drug delivery several-fold.

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