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BCL peptide

[NCAM BCL peptide] This peptide, NLIKQDDGGSPIRHY, corresponding to rat NCAM(631-645), is derived from the second fibronectin type 3 repeat module of NCAM [neural cell adhesion molecule]. BCL peptide acts as a FGF mimetic peptide in that it binds and activates FGFR1 and induces FGFR-dependent neurite outgrowth in cultures of cerebellar granule neurons. Unlike the FGL peptide from the same loop, however, BCL peptide does not promote neuronal survival (Jacobson et al, 2008).

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