bar-cells |
BARD1-beta |
PCT |
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[BRCA1-associated RING domain protein] BARD1 is a nuclear protein that dimerizes with another protein, BRCA1, and plays important roles in cellular response to DNA damage. This complex has the activity of a ubiquitin ligase, whereas individually BRCA1 and BARD1 have very low ubiquitin ligase activities in vitro (Hashizume et al, 2001; Xia et al, 2003). The BRCA1/BARD1 heterodimer directs polymerization of ubiquitin primarily through an unconventional linkage involving lysine residue K6 (Wu-Baer et al, 2003. These polyubiquitin chains are deubiquitinated by 26S proteasome in vitro (Nishikawa et al, 2004).
BARD1 undergoes phosphorylation upon ionizing radiation or UV radiation. DNA
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