BAECs |
BAF |
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[bovine artery endothelial cells growth-suppressing factor] This biochemically uncharacterized factor of approximately 65 kDa was purified from the conditioned medium of a mouse lymphoma P388D1 cell culture (Usui et al, 1999). The factor suppresses the growth of bovine artery endothelial cells. This activity is not inhibited by antibodies against TGF-beta, TNF-alpha, IL1, which have been reported to inhibit growth of bovine artery endothelial cells. The factor is a potent inhibitor of angiogenesis and causes regression of tumors after intravenous administration to tumor-bearing mice
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