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[apolipoprotein L9b] Kreit et al (2014) have reported that mouse ApoL9b, which has an intracytoplasmic localisation, is an antiviral interferon-stimulated gene active against Theiler’s murine encephalomyelitis virus (TMEV or Theiler’s virus). Weak expression of Apol9 in mouse primary neurons treated with type 1 interferons contributes to the surprising susceptibility of these cells to virus infection (For a highly related protein with similar activity see: Apol9a).

Kreit et al (2015) have shown that Apol9b inhibits replication of Theiler's murine encephalomyelitis virus (TMEV) but not replication of vesicular stomatitis virus, Murid herpesvirus-4, or infection by a lentiviral vector. Apol9b is strongly expressed in ... ... ... ... ... Subscribe to continue reading! ... ...


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