Agkistin

This protein, identified in the venom of the snake Agkistrodon halys, is a snake venom metalloproteinase. The gene has been cloned by Wang et al (2003). Yeh et al (2000) have reported that Agkistin is a platelet glycoprotein Ib antagonist and acts as an antiplatelet aggregation activity by disrupting the binding of von Willebrand factor to the platelet glycoprotein. Agkistin also selectively blocks the interaction of von Willebrand factor with human endothelial platelet glycoprotein Ib and inhibits angiogenesis in the Chicken chorioallantoic membrane assay. Agkistin can also induce apoptosis of human mammary epithelial cells (Wang et al, 2003).

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Entry last modified: March 2013