Achatin
also: Achatin-1, Achatin-I. Achatin is an endogenous neuropeptide containing a D-amino acid (Gly-D-Phe-Ala-Asp; GFAD) purified from the suboesophageal and cerebral ganglia of the African giant snail Achatina fulica Férussac. Achatin-2 (Achatin-II) is its L-Phe-containing stereoisomer.
Achatin evokes a potent neuroexcitatory effect, inducing a voltage-dependent inward current on giant neurons (Kamatani et al (1989). Kim et al (2001) have proposed that achatin acts as an excitatory neurotransmitter on Achatina neurons. Fujimoto et al (2001) have isolated Achatin from the snail's heart atria. Centrally, this peptide
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