ASC |
Ascaphin-1 |
MT-MMP-6 |
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[apoptosis-associated speck-like protein containing a CARD2] This is another designation for POP-1 [pyrin-only protein 1]. See: PYDC1 [pyrin domain-containing 1].
The protein is expressed predominantly in macrophages and granulocytes and suppresses NF-kappa-B activation in response to cytokines in a process involving the ASC/TMS-1 (target of methylation-induced silencing) adaptor protein (Stehlik et al, 2003).
The three-dimensional structure and dynamic properties of the protein have been described by Natarajan et al (2006).
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