AOPDM1

[anti-obesity peptide derived from breast milk 1] This peptide with the sequence AVPVQALLLNQ (Ala-Val-Pro-Val-Gln-Ala-Leu-Leu-Leu-Asn-Gln) has been isolated from human milk (Li et al, 2021). The peptide has been shown to reduce lipid storage in adipocytes. It suppresses adipocyte differentiation by sustaining extracellular signal-regulated kinase ERK activity at later stage of differentiation which down-regulates PPAR-gamma expression. In vivo, AOPDM1 effectively reduces fat mass and improves glucose metabolism in high-fat diet-induced obese mice and obese ob/ob ... ... ... ...
 
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Entry last modified: April 2021