ALG4

[Apoptosis-linked gene-4] This gene has been identified during studies of apoptosis induced by T-cell receptor engagement (Lacana and D'Adamio, 1999). Another designation is PDCD11 [programmed cell death-11]. The cDNA for this gene has been identified by Nagase et al (1996) as KIAA0185.

Various truncated transcipts have been found. The truncated transcript ALG4F prevents T-cell receptor induced upregulation of FAS ligand and cell death. Overexpression of full-length ALG4 induces transcription of FAS ligand and apoptosis.

PDCD11 is a NF-kappa-B binding protein ... ... ... ...
 
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Entry last modified: November 2010