ADAMTSL6

[ADAMTS-like-6] The approved gene symbol is THSD4 [thrombospondin type 1 domain containing 4]. ADAMTSL6 is an extracellular matrix protein and has been shown to promote the assembly of fibrillin-1 microfibrils (Tsutsui et al, 2010). Two splice variants have been identified in mice. ADAMTSL6-alpha and ADAMTSL6-beta are expressed in mouse embryos at all developmental stages, but the beta isoform appears to show a more tissue-restricted expression (Tsutsui et al, 2010).

Saito et al (2011) have implicated ADAMTSL6 in embryonic mouse tooth germ development. ADAMTSL6-alpha is expressed only in odontoblasts. Expression of the ... ... ... ...
 
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Entry last modified: October 2016