ADAMTS5
[a disintegrin and metalloproteinase with thrombospondin motif-5; ADAM metallopeptidase with thrombospondin type 1 motif 5] This protein is a member of the ADAM protein family (see: ADAMTS protein family). It is known also as Aggrecanase-2, a protein that cleaves Aggrecan, the major proteoglycan of cartilage (Abbaszade et al, 1999). Human ADAMTS5 has much higher aggrecanolytic activity than human ADAMTS4 (Fushimi et al, 2008).
The protein has been referred to previously as ADAMTS11 (Abbaszade et al, 1999) and has been referred to also as implantin.
The gene encoding this protein has been identified originally in an EST
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