ADAMTS15 |
ADAMTS17 |
PEMT |
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[a disintegrin and metalloproteinase with thrombospondin motif-16; ADAM metallopeptidase with thrombospondin type 1 motif 16] The cDNA for this member of the ADAMTS protein family has been cloned. The protein shows a domain organisation similar to that of other characterized members of this protein family. The gene is expressed mainly in fetal lung and kidney. It is expressed also in adult brain (Cal et al, 2002).
Surridge et al (2009) have cloned the cDNA and reported that stable over-expression of ADAMTS16 in chondrosarcoma cells leads to a decrease in cell proliferation and migration, though not adhesion, as well as a decrease in the expression of MMP-13
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