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ADAMTS1

[a disintegrin and metalloproteinase with thrombospondin motif-1; ADAM metallopeptidase with thrombospondin type 1 motif 1] This protein is a member of the ADAM protein family (see: ADAMTS protein family) (Kuno et al, 1997). It has been identified originally as a cDNA found in heart and lung tissues. The cDNA encoding ADAMTS1 has been identified independently as KIAA1346. Vázquez et al (1999) have referred to the protein as METH-1 (an acronym reflecting the novel combination of metalloprotease domains and thrombospondin domains). Kuno et al (1997) have identified the gene in a screen for genes selectively expressed in the cachexigenic colon 26 adenocarcinoma subline in vivo.

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Entry last modified: March 2006

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