AC6.21

a murine stromal cell line that has been used for the long-term ex vivo maintenance and expansion of transplantable human hematopoietic stem cells (see also: BMC).

The conditioned medium of these cells contain an activity, designated SCEPF (stem cell expansion promoting factor), that appears to be required for its function as feeder cells promoting the long-term growth of human CD34(+) cells.

The conditioned medium of this cell line also contains IL6, which has been shown to be responsible for the ability of the AC6.21 ... ... ... ...
 
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Entry last modified: March 2012