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vesiculin

This name has been given by Buchanan et al (2010) to an IGF-2-like immunoreactive protein isolated from secretory granules of the beta-cell line betaTC6-F7. Vesiculin is a two-chain insulin-like product of IGF-2 that corresponds to mouse des(37-40)IGF-2, which justifies its inclusion in the list of cryptides. Vesiculin is the major IGF-2-like peptide found in purified mouse betaTC6-F7 secretory granules. It stimulates ex vivo muscle glycogen synthesis with an efficacy greater than or equal to the intrinsic potency of IGF-2 when compared to insulin derived from the same species.

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