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vICA

[viral inhibitor of caspase activation] [Cytomegalovirus UL36 protein] This protein, also termed: pUL36, HCMV UL36 [Human cytomegalovirus UL36 protein], is encoded by the UL36 open reading frame in the genome of human cytomegalovirus (HCMV). UL36 is nonessential for growth in cultured cells (Patterson and Shenk, 1999) and many laboratory strains of the virus do not contain this gene (Skaletskaya et al, 2001).

Most or all mammalian betaherpesviruses encode sequence homologs of HCMV vICA, implying that the function of vICA is important and conserved (McCormick et al, 2003). The ... ... ... ... ... Subscribe to continue reading! ... ...

 

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