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vIBO

[viral inhibitor of Bak oligomerization] This protein, named by Cam et al (2010), is encoded by open reading frame m41.1 of MCMV [murine cytomegalovirus] (MCMV m41.1; murine cytomegalovirus m41.1). Rat CMV contains a related gene, but a sequence homolog to m41.1 is not present in the genome of human CMV. The protein is localized to mitochondria, interacts with BAK, and inhibits its oligomerization, thereby blocking BAK-dependent cytochrome C release and cell death by apoptosis.

Crosby et al (2013) have reported that vIBO is required for optimal viral replication in ... ... ... ... ... Subscribe to continue reading! ... ...

 

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