triose phosphate isomerase

abbr. TPI, which is the same as TPI1 [triose phosphate isomerase 1]; abbr. frequently also: TIM. Alternative designations for this enzyme are Triose phosphoisomerase, Triosephosphate mutase, Phosphotriose isomerase.

This enzyme (EC5.3.1.1) is a homodimeric enzyme that catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate during glycolysis and gluconeogenesis. The enzyme, which does not require any ion or cofactor to perform its catalytic function (Alber et al, 1981; Wierenga et al, 2010), is responsible for the net gain of ATP as well as the production of an extra molecule of pyruvate per ... ... ... ...
 
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Entry last modified: January 2020