sFRP3 |
sFRP5 |
lukF |
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[secreted frizzled-related protein 4] This protein (346 amino acids), which is being referred to also as FRP4 [frizzled-related protein 4], is a member of a family of secreted proteins that appear to act as soluble modulators of Wnt family signaling. They compete with membrane-bound receptors belonging to the frizzled family for the binding of secreted Wnt family ligands (Jones and Jomary, 2002).
The gene encoding this protein has been identified originally by Rattner et al (1997) as a member of a family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand binding domain found in the frizzled
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