receptor protein tyrosine kinases |
receptor protein tyrosine phosphatase-beta |
red cells |
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[receptor protein tyrosine phosphatases]
abbr. RPTPs. These proteins constitute a family of proteins and have been found in a variety of different vertebrate and invertebrate systems (Paul and Lombroso, 2003; Johnson and Van Vactor, 2003; Avraham et al, 2000). The extracellular domains of these proteins show a great diversity and often contain sequence motifs resembling those present in many cell adhesion molecules. In addition, these proteins also contain an intracellular domain possessing phosphatase activity.
These phosphatases can bind to themselves (homophilic) and to other proteins (heterophilic) (Beltran and Bixby, 2003). Unlike intracellular protein phosphatases, these enzymes are localized in the membrane and can serve as signaling receptors that dephosphorylate
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