proBac7 |
proBDNF |
BCL2-like-4 |
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[pro-B-cell]
also: pro-B-lymphocytes. Pro-B-cells, defined as CD19(+) CD34(+) CD10(+) IgM(-), are an early identifiable intermediate cell type in a series of developmental stages eventually leading to the generation of mature B-cells. Pro-B-cells develop from hematopoietic stem cells derived from fetal liver (Hardy and Hayakawa, 2001; Osmond, 1990). Pro-B-cells further develop into pre-B-cells, defined as CD19(+) CD34(-) CD10(+) IgM(-), following induction of recombination-activating genes RAG1 and RAG2 and production of the heavy chain immunoglobulin (Ig) (Schatz and Baltimore, 2004). These cells then then yield cells
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