Pre-B-cell growth stimulating factor |
pre-B-lymphocyte gene 1 |
melanoma-initiating cells |
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[pre-B-cell]
also: pre-B-lymphocytes. One identifiable intermediate cell type in a series of developmental stages leading to the generation of B-cells (Hardy and Hayakawa, 2001). Pre-B-cells develop from pro-B-cells and are defined as CD19(+) CD34(-) CD10(+) IgM(-) (Schatz and Baltimore, 2004).
Two types are distinguished. Large pre-B-cells are characterized by the presence of VDJ rearranged H chain genes, germline L chain genes, the expression of m chains in pre-B receptors, absence of expression of RAG recombinase and TdT, expression of surrogate L chains, Ig antibody expression, expression of BTK. The cells also express markers such as CD45R,
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