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obd

[out of bounds] Mutations in obd have been shown to affect angiogenesis in zebrafish. In obd mutants, all angiogenic cell fates are generated, but sprout launching and growth of intersegmental vessels that sprouts from the aorta are not restricted to the intersegmental region. These intersegmental vessels sprout precociously at abnormal sites and migrate anomalously in the vicinity of ventral somite. The dorsal extent of the intersegmental vessels is less perturbed. Precocious sprouting can be inhibited in a VEGF morphant, but the anomalous site of origin of obd intersegmental vessels remains.

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