Natural suppressor cell-derived suppressor factor |
NAV1 |
ribonuclease 3(1-45) |
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[natural suppressor cell]
abbr. NS cells. Natural suppressor cells constitute a population of antigen-nonspecific, MHC-independent immunoregulatory immune cells identified originally by their ability to suppress various immune responses in a nonspecific and unprimed manner (Strober, 1984; Maier et al, 1987) and the absence of lineage-specific cell surface markers (see also: null cells).
These cells have been found at sites of active hematopoiesis such as bone marrow (Mortari et al, 1986), neonatal spleen (Rodriguez et al, 1979; Jadus and Parkman, 1986), and the spleen of mice after total lymphoid irradiation (Weigensberg et al, 1984; May et al, 1983). Natural suppressor cell activity has been shown to be enriched in the fraction of hematopoietic progenitor cells
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