Motch B |
Mothers against decapentaplegic |
cTAGE5 |
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Name of a mutation that arose spontaneously in C57BL/6J mice. The mutation maps to the distal end of chromosome 6. Two alleles of this locus are known, designated me and mev (viable me). The disease in homozygotes of mev/mev is very similar to that of me/me mice but progresses more slowly.
A few days after birth animals homozygous for the recessive me locus develop subepidermal lesions, which disrupt hair follicles and pigmentation and give the mice their characteristic motheaten appearance. The animals suffer from an early onset autoimmunity and severe immunodeficiency. Even under specific pathogen-free conditions animals die
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