lys-5 |
Lys7-Dermorphin |
TSWSPCSASCGGGHYQRTR |
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[lysozyme-7] This Caenorhabditis elegans gene is one of several paralogs encoding a putative lysozyme and plays a role in innate immunity. It encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica.
Expression of lys-7 is induced strongly upon exposure to Serratia marcescens (Mallo et al, 2002), Microbacterium nematophilum (O'Rourke et al, 2006), and Salmonella typhimurium (Evans et al, 2008). Silencing of lys-7 expression enhances the susceptibility to Microbacterium nematophilum (O'Rourke et al, 2006). Marsh et al (2011) have reported that the deletion of lys-7 renders Caenorhabditis elegans susceptible to killing by the fatal fungal human
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