lpr
[lymphoproliferative] A recessive mutation observed during inbreeding in a stock derived from mouse strains LG, AKR, C3H, and C57BL/6. The mutation gld (generalized lymphoproliferative disease) produces an abnormal T-cell population indistinguishable from that of lpr (see also: FAS ligand). For a human counterpart see also: ALPS [autoimmune lymphoproliferative syndrome]. The lpr and gld genes are a FAS deletion mutant and a FAS ligand mutant, respectively (for overview see: Cohen and Eisenberg, 1991, 1992; Nagata and Suda, 1995; Nose et al, 2000).
Homozygotes of inbred MRL/lpr (Murphy Roths Large/lpr
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