lipoamide dehydrogenase |
lipoblasts |
Cytotoxicity stimulating factor-L3 |
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The terms lipid-induced cell death and lipotoxic cell death have been used to refer to this cause of cell death. Another term describing cell death by lipoapoptosis is palmitate-induced cell death, because palmitate is the most abundant saturated free fatty acid. Lipoapoptosis is a metabolic cause of cell death by apoptosis caused by exposure of nonadipose tissues to an excess of long-chain fatty acids (Unger and Orci, 2002; Unger, 2002; Unger, 2003). Leptin action increases their oxidation sufficiently, whereas unoxidized
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