KRHHGYKR |
kringle containing transmembrane protein |
Proopiocortin |
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The name of this structural protein domain derives from its resemblance to Danish pastries known as kringlers. These domains are triple-disulfide-linked peptide regions of approximately 80 amino acids.
Kringle domains are found in a varying number of copies in some serine proteases and plasma proteins that aevolved from an ancestral gene with a single copy of the kringle domain and that constitute the kringle-serine proteinase superfamily (KSP superfamily of proteins (Gherardi et al, 1997). Kringle domains
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