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ird5

[Immune response deficient 5] The Drosophila melanogaster ird5 gene has been identified in a genetic screen for Drosophila immune response mutants (Lu et al, 2001). The ird5 gene (CG4201) encodes a Drosophila homolog of mammalian I-kappa-B kinase (IKK-beta). Mutations in ird5 prevent the induction of six antibacterial peptide genes (Diptericin, Cecropin A, Defensin, Attacin, Drosocin, and Metchnikowin) in response to infection but do not affect the induction of the antifungal peptide Drosomycin ... ... ... ... ... Subscribe to continue reading! ... ...

 

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