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intrakine

[intracellular chemokine] this term refers to a strategy essentially producing a knock-out phenotype for a (cytokine) receptor by blocking the cell surface expression of newly synthesized receptor proteins (Yang et al, 1998). Engel et al (2000) have observed that an intrakine (an engineered form of SDF-1-alpha) may also be secreted and cause the downregulation of the corresponding receptor by acting like a secreted chemokine.

In one case a member of the chemokines (CC-Chemokines) (the intrakine; see also: Recombinant cytokines, Muteins) was targeted to the endoplasmic reticulum where the corresponding receptor is synthesized before it is transported to the plasma membrane. This is achieved by fusion of the ... ... ... ... ... Subscribe to continue reading! ... ...

 

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