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innate-like B-cells

[innate-like B cell]

This collective term usually refers to two subsets of B-cells, marginal zone B-cells and B-1 cells, that differ from the vast majority of conventional B-cells (follicular B-cells) by their ability to quickly differentiate into antibody-secreting cells producing natural polyreactive antibodies in response to stimulation by ligands of Toll-like receptors (Martin and Kearney, 2000; Rubtsov et al, 2008; for overview see also: Tsay and Zouali, 2018). This is in contrast to follicular B-cells, which produce specific antibodies with much slower kinetics and require stimulation by both B-cell receptor and Toll-like receptors for differentiation into ... ... ... ... ... Subscribe to continue reading! ... ...

 

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