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hyt

[hyt/hyt]

[hypothyroid] Hyt is an autosomal recessive mutation that causes hypothyroidism in mice. Mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility (Beamer et al, 1981; Beamer and Cresswell, 1982). Stein et al (1994) have identified a point mutation in transmembrane region of the thyrotropin receptor TSHR as the underlying cause of the genetic defect.

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