hpg

[hypogonadal] hpg is an infertile mouse mutant (Cattanach et al, 1977; Mason et al, 1986) due to a congenital deletion of the gene encoding GNRH [gonadotropin releasing hormone]. The absence of GNRH in this naturally occurring knock-out mouse results in a markedly reduced pituitary content of LH [luteinizing hormone], FSH [follicle-stimulating hormone], and undetectable or barely measurable serum gonadotrophin levels (Cattanach et al, 1977; Charlton et al, 1983). Ovaries and testes fail to undergo normal postnatal development (Cattanach et al, 1977, 1977), and in adult hpg males, serum ... ... ... ...
 
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Entry last modified: December 2013