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hpg

[hypogonadal] hpg is an infertile mouse mutant (Cattanach et al, 1977; Mason et al, 1986) due to a congenital deletion of the gene encoding GNRH [gonadotropin releasing hormone]. The absence of GNRH in this naturally occurring knock-out mouse results in a markedly reduced pituitary content of LH [luteinizing hormone], FSH [follicle-stimulating hormone], and undetectable or barely measurable serum gonadotrophin levels (Cattanach et al, 1977; Charlton et al, 1983). Ovaries and testes fail to undergo normal postnatal development (Cattanach et al, 1977, 1977), and in adult hpg males, serum ... ... ... ... ... Subscribe to continue reading! ... ...

 

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