Esculentin-1(1-18) |
ESDN |
KSHV viral IL6 |
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Esculentin (GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC with a C-terminal disulfide bridge) is an antimicrobial peptide isolated from skin secretions of the European frog, Rana esculenta (Simmaco et al, 1993). Mangoni et al (2003) have reported that frog skin secretions also contain the 19-46 fragment of esculentin-1 (termed esculentin-1b), which is devoid of antibacterial activity. Esculentin-1(1-18) is the N-terminal fragment (1-18) of esculentin-1. It is highly active against most bacterial and fungal species, although at a lower extent than the full-length peptide. Esculentin-1c is a 46 residue
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