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ehcp5

[Entamoeba histolytica cysteine proteinase-5] One of several cysteine proteinases encoded in the genome of the protozoan parasite Entamoeba histolytica. This parasite causes intestinal inflammation and ulceration. ehcp5 and other pathogen-encoded cysteine proteases have been shown to be important virulence factors.

The enzyme possesses IL1-beta Convertase activity, which is thought to contribute to intestinal inflammation by activating human IL1-beta released by damaged intestinal cells (Zhang et al, 2000). Entamoeba histolytica trophozoites lacking expression of ehcp5 do not induce intestinal epithelial cell production of the inflammatory cytokines IL1beta and ... ... ... ... ... Subscribe to continue reading! ... ...

 

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