dll4
[delta-like-4; Drosophila delta homolog 4; also: delta-like ligand-4] Another term is delta-4. dll4 is a membrane-bound ligand for Notch, specifically Notch-1 and Notch-4 (Krebs et al, 2000), characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. The ligand is expressed selectively in the vascular endothelium (Shutter et al, 2000).
Dll4 appears to play a role in the development of T-cells as bone marrow, spleen, lymph nodes, and peripheral blood of dll4 overexpressing mice contain predominantly CD4(+) CD8(+)
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