delta-4

This protein has been identified as a ligand for Notch-4 (Yoneda et al, 2001; Rao et al, 2000). The protein is the same as dll4 [delta-like-4].

Delta-4 mRNA is abundant in squamous alveolar cells neighboring endothelial cells that express Notch-4. Soluble forms of the extracellular portion of Delta-4 inhibit the proliferation of human aortic endothelial cells, but not human pulmonary arterial endothelial cells

Murine Delta-4 is highly expressed in the eye and lung during embryogenesis and in the heart, lung, liver, and kidney of the adult (Rao et al, 2000). Functionally, Delta-4 is indistinguishable from Jagged-1 ... ... ... ...
 
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Entry last modified: January 2003