dUTPase
also: deoxyuridine triphosphatase, Deoxyuridine 5′-triphosphate nucleotidohydrolase, dUTP pyrophosphatase (EC3.6.1.23).Approved gene symbol: DUT. Ladner and Caradonna (1997) have cloned the human dUTPase gene and shown that it encodes both nuclear and mitochondrial isoforms. For virus-encoded counterparts of this enzyme see: viral dUTPases.
This enzyme catalyzes the production of dUMP, the immediate precursor of thymidine nucleotides, by hydrolyzing dUTP to dUMP and pyrophosphate (Ladner and Caradonna, 1997). dUMP is a substrate for thymidylate synthase
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