DT2P1G7 |
dTCTP-binding protein 2 |
apical caspases |
||
[dTCTP-binding protein 2] This peptide with the sequence WYVYPSM (Trp-Tyr-Val-Tyr-Pro-Ser-Met), identified by phage display, has been reported to bind to dimeric forms of TCTP [translationally controlled tumor protein = IgE-HRF [IgE-dependent histamine releasing factor]] and to inhibits its cytokine-like effects (Kim M et al, 2011, 2013). In a mouse model of house dust mite-induced atopic dermatitis topical administration of dTBP2 significantly reduces skin lesions and mast cell infiltration. Treatment with dTBP2 also decreases the serum levels of IgE and reduces IL17A content in skin lesions and inhibits the expression of mRNAs of
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