connector neurons |
Conopressin-G |
SMAD3 |
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This bioactive peptide fragment (see also: cryptides) is derived from CTGF, a member of the CCN family of secreted cysteine-rich growth regulators that is a growth factor secreted by endothelial cells (Karagiannis and Popel, 2007). Connectostatin [CTGF(204-221)] [TEWSACSKTCGMGISTRV] corresponds to residues 204-221 of CTGF (Karagiannis and Popel, 2008).The primary structure of this peptide is similar to the thrombospondin type 1 domains found in thrombospondin-1, thrombospondin-2, the metalloproteinases ADAMTS1 and ADAMTS8. The peptide
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