cbl

An oncogene, termed v-cbl, detected initially as the transforming gene in the genome of the murine Cas NS-1 retrovirus. This virus induces pro-B, pre-B and myeloid tumors in mice inoculated at birth. Sequencing of c-cbl, the cellular homolog of the viral oncogene, has revealed that the viral oncogene has been generated by a large truncation that removes 60 % of the C-terminus of the corresponding protein. The truncated protein is a DNA-binding transcription factor.

The gene for human c-cbl is located on chromosome 11q23.3, which is in the region of translocation breakpoints in a range of acute leukemias. The ... ... ... ...
 
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