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altFGF2

altFGF2 (21.5-kDa) is a variant form of bFGF. Its amino-terminal domain diverges completely from the other splice forms of bFGF. In contrast to bFGF, the altFGF2 protein is targeted predominantly to the endoplasmic reticulum.

The protein is expressed abundantly during chicken embryogenesis. The altFGF2 isoform is distributed in a dynamic, spatially restricted pattern in notochord and ventral neural tube (floor plate and motor neurons) during specification of neuronal populations. Dorsal expression of altFGF2 induces alteration of neural tube morphology.

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