aggrephagy

The term aggrephagy (Lamark and Johansen, 2012) refers to a specific process of autophagy permitting the degradation of nonfunctional misfolded or disease-associated toxic proteins in the cell under conditions when other mechanisms are overwhelmed and fail, for example recognition and polyubiquitination of misfolded proteins by a complex set of enzymes and their subsequent degradation by the ubiquitin-proteasome system (Johnston et al, 1998; Tyedmers et al, 2010; Zhang and Qian, 2011). The term aggresome pertains to a cellular structure, a prominent inclusion body localized at the perinuclear region of the cell, that is thought to play an important role in managing the degradation of such protein aggregates.

Aggresomes are composed mainly of aggregated, undegraded misfolded proteins and are subject to clearance by macroautophagy ... ... ... ...
 
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Entry last modified: September 2017