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YPHIDSLGHWRR

This peptide, described originally as Peptide YR (Hardy et al, 2000) and renamed Peptide RoY (Hardy et al, 2008) has been identified by phage display library screening human vascular endothelial cells under different physiological conditions. Under hypoxic conditions YPHIDSLGHWRR induces increases endothelial cell proliferation, migration, and tube formation (Hardy et al, 2008). The peptide does not induce the expression of VEGF receptors (Hardy et al, 2000) but binds to an N-terminal region of GRP78, the expression of which is upregulated in endothelial cells under hypoxia (Hardy et al, 2008). In a mouse ... ... ... ... ... Subscribe to continue reading! ... ...

 

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