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abbr. WLS (which is also the approved gene symbol). A previous symbol is C1orf139 [chromosome 1 open reading frame 139].

Wntless is a multipass transmembrane protein that is highly conserved in metazoans from worms to humans. For example, human Wntless is 96 % identical to mouse Wntless and 78 % identical to the zebrafish protein. The protein is expressed ubiquitously in many tissues and cell types (Jin et al, 2010; Wang et al, 2012; Yu et al, 2010).

Bänziger et al (2006) have identified Wntless as a component of the Wnt pathway that is required for the secretion of Wnt proteins. Wntless is required for patterning processes in Drosophila dependent on ... ... ... ... ... Subscribe to continue reading! ... ...


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