Wnt-inhibitory factor-1 |
Wnt modulator in surface ectoderm |
mTR |
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abbr. WLS (which is also the approved gene symbol). A previous symbol is C1orf139 [chromosome 1 open reading frame 139].
Wntless is a multipass transmembrane protein that is highly conserved in metazoans from worms to humans. For example, human Wntless is 96 % identical to mouse Wntless and 78 % identical to the zebrafish protein. The protein is expressed ubiquitously in many tissues and cell types (Jin et al, 2010; Wang et al, 2012; Yu et al, 2010).
Bänziger et al (2006) have identified Wntless as a component of the Wnt pathway that is required for the secretion of Wnt proteins. Wntless is required for patterning processes in Drosophila dependent on
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